.Nature Medication, Posted online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic evaluations revealed that an unfamiliar reassortant virus-like family tree of the Oropouche virus, which has been spreading in the western Amazon area of South america for concerning a years, is connected with the recent human break outs between 2022 and 2024.